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The most frequent issues reported from the phase 3 studies are nausea (19%), fatigue (6%), skin darkening (4%), dizziness (4%), and the development of moles (4%)
*** poor solubility in culture medium and toxicity against cells
GLP-1 is a natural hormone that plays an important role in metabolic homeostasis and healthy weight regulation
Mounjaro has been FDA-approved for managing type 2 diabetes
Its only incretin-adjacent action is dipeptidyl peptidase-4 inhibition, which the article calls indirect and weaker
However, post-marketing surveillance through systems such as the MHRA Yellow Card Scheme suggests that taste changes may occur in some patients, though the exact frequency is difficult to quantify
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